The largest river in the region of Leskovac is the Južna (South) Morava River, which flows South to North, and together with the Zapadna (West) Morava River forms the Velika (Great) Morava River. Tributaries of the Južna Morava are: the Vlasina river, which collects water from Lake Vlasina and flows through Crna Trava and Vlasotince; the Veternica river, which flows through Leskovac;

The Jablabica river, which springs from the foot of Goljak and flows through Medveđa and Lebane; the Pusta (Deserted) river, which starts on Radan mountain, fills Lake Brestovačko and flows through Bojnik. The river Vučjanka, which springs from the Kukavica mountain, flows through Vučje and is a tributary of the Veternica river. The river Vučjanka, which springs from the Kukavica mountain, flows through Vučje and is a tributary of the Veternica river. Also known in the Leskovac region are The Kozaračka, Predejanska, Kopašnička and Sušica rivers.

The natural resources of the Leskovac region are favorable for a great diversity of plant and animal life. The most widespread of animals are: roe deer, wild boar, hare, partridges and pheasants, while the plant world is noted for a very diverse presence of medicinal and other useful plants. The first floristic investigations in this territory were carried out by the founder of Serbian botany Josif Pancić towards the end of the 19th century.

Together with hicillaborators he found an exceptionally rare plant at Ostorzub, the endemorelict lovorvišnja, zelenoče (Prunus Laurocerasus). For over one hundred years this plant occupied the attention of botanists from all over the world, because until then, it was only found in Bulgaria, and 2-3 other localities.

Because of this Ostrozub was declared a strict natural reservation. The Leskovac region possesses more than 50 other rare (mostly medicinal) plants, oedemas etc.

Rostiljijada-(Barbecue week) - is a grill-meat festival that has been organized in Leskovac for many years, which takes place each year at the beginning of September. During the event, the main boulevard is closed for traffic, night and day for five days, and all its way there are grill-stands constructed, to create many temporary restaurants. Many visitors from all over Serbia and many tourists come to Leskovac to enjoy a good grill and entertainment. The organisers hold competitions, such as in making the biggest burger - the pljeskavica. The festival is the highlight of the season in Leskovac.

In 2009 Leskovac officially became a International Carnival city, admitted by The Association of European Carnival cities, which has over 50 members from Europe and America. The Leskovac Carnival is held in a time of Rostiljijada festival. Around 1200 people take part in the carnival, of which one third part from abroad. The City Government considers to separation this event in 2010. as a special tourist event which gonna be introduced as a special offer of the city.

Theater Marathon, takes place every year in November and lasts 9 days. It runs performances of National Theaters from all over Serbia. This event takes place in Nardonom Theater in Leskovac.

First International film festival was held in 2008. The idea of the film in the city is not that new. In 1996, a group of enthusiasts, with chairman Rade Jovic, organized the Festival which were shown films of domestic production. Today, many years later, Leskovac host an International Film Festival. The Festival presents awards in 3 categories: - "Golden hazelnuts" - Best Director - "Hazelnut leaf" - critics awards - "Vox populi" - Audience Award.

Leskovac is also a traffic junction of sorts. International trains traveling from Europe to Skoplje, Thessalonica and Athens pass through this city. Nineteen trains stop in Leskovac every day. The railway came to Leskovac in 1886. Leskovac today has one of the newest and most modern railway stations in Serbia.

Bus traffic is also very well developed, bearing in mind that Leskovac has been criss-crossed with roads. The most important is the E 75 road which connects the borders of Hungary and Macedonia. Regional roads lead from Leskovac to Priština, Pirot and Bosilegrad. The distance from Leskovac to Niš is 45, to Belgrade 280, and to Sofia 155 kilometers.

Leskovac has a regional airport, which is commonly used for sporting and agricultural flights. Also in summer the airport is used for air taxi. The nearest international airport is The Constantine the Great Airport located 45km from city center.

Leskovac is the first city in Serbia which has a sanitary landfill. Željkovac depot spreads over 80 hectares and is made by all European standards. In the landfill there is a center for atmospheric water purification, center for the selection and disposal systems for the detection of all types of pollution. Company Por Werner and Weber for Serbia, began construction of the center for collecting and recycling waste, and is the first city in the Balkans, where starting this job.